Higher‑Intensity Topicals
Clinical‑forward routines often rely on leave‑on steps paired with balanced in‑wash prep to support cosmetic changes in the look of density.
Human • Routine design
The Science
Sempre — TR6™
Our highest‑intensity system featuring TR6™—designed to support the look of visibly denser hair and a revitalized scalp appearance when used consistently.
Not sure if Sempre is right? Try the Regimen Finder →
Mechanism of Action
How TR6™ Is Positioned
- Higher‑intensity approach: Built for users seeking more robust cosmetic support for the look of thinning hair.
- Rinse + leave‑on architecture: In‑wash steps prep; leave‑on phases provide extended contact.
- System thinking: Designed to complement a routine that can include alternating with Naturale or Buongiorno for comfort/freshness days.
High intensity • Routine‑based • Color‑safe
System Design
Formulation & Use
- Phased routine: Cleanse/condition 3–5× weekly; apply leave‑on step daily on clean scalp.
- Texture & finish: Non‑greasy finishes engineered to reduce the look of buildup.
- Guidance: If irritation occurs, reduce frequency or alternate with Naturale/La Rosa and consult your clinician.
Need help choosing?
Answer a few questions to find the right collection intensity for you.
Try the Regimen FinderCompare Growth Strength
Qualitative guide across collections
Sempre
Clinical-intensity support (TR6™) for advanced thinning & visible regrowth aesthetics.
Naturale
Moderate strength — DHT‑aware, gentle for sensitive scalps.
Buongiorno
Moderate strength — daily scalp vitality & refresh.
La Rosa
Light strength — rose‑infused care focused on scalp comfort.
This meter is a qualitative guide for comparing collection intensity levels; individual results vary. For a tailored routine, try the Regimen Finder.
Key Evidence
What the Literature Explores
System Thinking
Combining compatible steps may help maintain consistent exposure and user tolerance—key for long‑term routine adherence.
Mechanism • Adherence
Comfort & Tolerability
Strategies include alternating days with comfort‑first collections and adjusting frequency if the scalp feels stressed.
Usage • Tolerability
Note: Cosmetic products support the look and feel of hair and scalp; individual results vary. Consult your clinician for diagnosis and treatment options.
Results Gallery
Visuals Shared From the Sempre Line
Related Reading
Studio, Spotlights & Deep Dives
Studio Integratori
Learn about our integrative approach to routine design and complementary support.
World’s Most Luxurious Shampoo?
The ingredient journey behind Sempre’s premium formulation philosophy.
Best Shampoo for Hair Growth?
How to evaluate growth‑minded shampoos from a cosmetic science lens.
Is it Really the Most Expensive?
A transparent look at sourcing, concentration, and value.
What’s in Growth Vitamins?
Main component families often used in hair & skin nutraceuticals.
Ingredient Spotlights
Botanicals Discussed in Our Ecosystem
Technology & Partners
TR6™ Context & Clinic Perspectives
External resources are provided for context; Sempre products are cosmetic and not drugs.
Further Evidence
Peer‑Reviewed Context
Botanical Actives & Hair/Scalp
Reviews survey cosmetic and adjunct uses of plant‑derived ingredients in hair/scalp care.
Review
Scalp Microbiome & Care
Emerging research discusses the scalp microbiome’s role and cosmetic care considerations.
Review • Microbiome
Hair Appearance & Interventions
Literature exploring various approaches to improving the look and feel of thinning hair in cosmetic contexts.
Review/Study
These links are for scientific context only and do not constitute product claims.
Safety
Who Sempre is For
- Those seeking a higher‑intensity routine for more pronounced cosmetic goals.
- Users comfortable with daily leave‑on steps and consistent routine adherence.
- If sensitivity arises, reduce frequency, alternate with Naturale/La Rosa, or consult your clinician.
Quality
Testing & Standards
- Formulas avoid sulfates, parabens, phthalates, and silicones.
- Routine stability, micro, and heavy‑metal testing per supplier standards.
- Ingredient selection emphasizes standardization and traceability.
FAQs
Science FAQs — Sempre
How is Sempre different from Naturale and Buongiorno?
Sempre is positioned as the highest‑intensity collection (TR6™). Naturale focuses on sensitive‑first (saw palmetto), Buongiorno on daily freshness (rosemary/tea tree).
How long until I notice a difference?
Consistency matters. Many cosmetic routines are evaluated over weeks to months of daily use; individual results vary.
Can I alternate Sempre with other lines?
Yes. Many use Sempre for higher‑intensity days and rotate Naturale or La Rosa for comfort, or Buongiorno for freshness.
What if my scalp feels stressed?
Reduce frequency, switch days, and consult your clinician. Discontinue if irritation occurs.
Which line should I choose?
Start with Compare Collections or try the Regimen Finder for tailored suggestions.
Ready for higher‑intensity support?
Explore the Sempre Collection or compare collections to find your ideal routine intensity.